血管升压素/催产素受体家族的分子神经生物学与药理学
Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.
作者信息
Peter J, Burbach H, Adan R A, Lolait S J, van Leeuwen F W, Mezey E, Palkovits M, Barberis C
机构信息
Department of Medical Pharmacology, Utrecht University, Netherlands.
出版信息
Cell Mol Neurobiol. 1995 Oct;15(5):573-95. doi: 10.1007/BF02071318.
Abstract
- VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors. 2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor. 3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed.
摘要
- 血管加压素（VP）和催产素（OT）通过4种受体亚型V1a、V1b、V2和OT受体介导它们丰富多样的效应。2. 在此，我们综述了关于VP/OT受体的药理特性、构效关系、配体特异性的物种差异、表达模式及信号转导的最新见解。3. 此外，还讨论了是否存在其他VP/OT受体亚型。
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