Fiorentino P M, Cairns B E, Hu J W
Faculty of Dentistry, University of Toronto, Ontario, Canada.
Arch Oral Biol. 1999 Jan;44(1):27-32. doi: 10.1016/s0003-9969(98)00095-8.
Application of the small-fibre excitant and inflammatory irritant mustard oil or the excitatory amino-acid receptor agonist glutamate to the rat temporomandibular joint (TMJ) region evokes similar changes in jaw-muscle activity, suggesting that peripheral application of glutamate may be nociceptive. Application of mustard oil to the TMJ region is also inflammatory, but, it is not clear if application of glutamate is equally inflammatory. In this study the extent of plasma-protein extravasation and oedema induced by mustard oil application to the TMJ region was compared with that induced by glutamate. Application of mustard oil resulted in plasma-protein extravasation into the TMJ tissues and oedema of the TMJ region. In contrast, glutamate did not cause plasma-protein extravasation or oedema.
将小纤维刺激剂和炎性刺激物芥子油或兴奋性氨基酸受体激动剂谷氨酸应用于大鼠颞下颌关节（TMJ）区域，会引起颌面部肌肉活动的类似变化，这表明外周应用谷氨酸可能具有伤害感受性。将芥子油应用于TMJ区域也具有炎症性，但尚不清楚应用谷氨酸是否同样具有炎症性。在本研究中，比较了将芥子油应用于TMJ区域所诱导的血浆蛋白外渗和水肿程度与谷氨酸所诱导的程度。应用芥子油导致血浆蛋白渗入TMJ组织以及TMJ区域水肿。相比之下，谷氨酸并未引起血浆蛋白外渗或水肿。
