来自日本杜茎山的新型三萜皂苷。

New triterpenoid saponins from Maesa japonica.

作者信息

Koike K, Kudo M, Jia Z, Nikaido T, Ide Y, Sakura T

机构信息

Department of Pharmacognosy, School of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.

出版信息

J Nat Prod. 1999 Feb;62(2):228-32. doi: 10.1021/np980235c.

DOI:10.1021/np980235c

PMID:10075747

Abstract

New triterpenoid saponins, maejaposides A, B, C, D, and E, were isolated from the roots of Maesa japonica and were, respectively, defined to be 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1-->2)-bet a-D-galactopyranosyl-(1-->3)] [beta-D-galactopyranosyl-(1-->2)]beta-D-glucuronopyranosides of 22alpha-[(Z)-2-hexenoyloxy]-13beta,28-oxido-olean++ +-16alpha, 28alpha-diol (1); 22alpha-[2'-methylbutanoyl]-13beta, 28-oxido-olean-16alpha,28alpha-diol (2a) and 22alpha-angeloyloxy-13beta,28-oxido-olean-16a lpha,28alpha-diol (2b); 21beta,22alpha-diangeloyloxy-13beta,28-oxido- olean-16alpha, 28alpha-diol (3); 21beta-angeloyloxy, 22alpha-(2'-methylbutanoyl)-13beta,28-oxido-olean++ +-16alpha, 28alpha-diol (4), and 21beta-angeloyloxy, 22alpha-[(Z)-2'-hexenoyl]-13beta,28-oxido-olean- 16alpha,28alpha-diol (5). Their structures were established on the basis of extensive NMR (DEPT, COSY, HOHAHA, HETCOR, HMBC, and NOESY) and ESIMS/MS studies, along with chemical degradation.

摘要

从日本杜茎山的根部分离出了新的三萜皂苷，即日本杜茎山皂苷A、B、C、D和E，它们分别被确定为22α-[(Z)-2-己烯酰氧基]-13β,28-环氧-齐墩果-16α,28α-二醇的3-O-[β-D-吡喃木糖基-(1→2)-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃半乳糖基-(1→3)] [β-D-吡喃半乳糖基-(1→2)]β-D-葡萄糖醛酸吡喃糖苷(1)；22α-[2'-甲基丁酰基]-13β,28-环氧-齐墩果-16α,28α-二醇(2a)和22α-当归酰氧基-13β,28-环氧-齐墩果-16α,28α-二醇(2b)；21β,22α-二当归酰氧基-13β,28-环氧-齐墩果-16α,28α-二醇(3)；21β-当归酰氧基,22α-(2'-甲基丁酰基)-13β,28-环氧-齐墩果-16α,28α-二醇(4)，以及21β-当归酰氧基,22α-[(Z)-2'-己烯酰基]-13β,28-环氧-齐墩果-16α,28α-二醇(5)。它们的结构是在广泛的核磁共振（DEPT、COSY、HOHAHA、HETCOR、HMBC和NOESY）和电喷雾电离质谱/质谱研究以及化学降解的基础上确定的。