Fukuyama Y, Minami H, Kagawa M, Kodama M, Kawazu K
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan, and Department of Bioresources, Okayama University, Tsushima, Okayama, 700-8530, Japan.
J Nat Prod. 1999 Feb;62(2):337-9. doi: 10.1021/np980338v.
Vibsanin E (4), a tricyclic vibsane-type diterpene, has been prepared in 50% yield from vibsanin C (2), a seven-membered ring vibsane-type diterpene by reaction with BF3.OEt2 at -78 degrees C. This chemical correlation not only established structure, including absolute configurations, but also has demonstrated a possible biosynthetic route to 4 via 2 derived from vibsanin B (1). The structure of 3-hydroxyvibsanin E (5), another example of a tricyclic seven-membered ring vibsane, isolated from the leaves of Viburnumawabuki, has been established by extensive analyses of 2D NMR data and comparison of its spectral data with those of 4.
卫矛宁E（4）是一种三环卫矛烷型二萜，由七元环卫矛烷型二萜卫矛宁C（2）在-78℃下与三氟化硼乙醚反应制备，产率为50%。这种化学关联不仅确定了其结构，包括绝对构型，还展示了一条从卫矛宁B（1）衍生的2经由4的可能生物合成途径。从珊瑚树叶片中分离得到的另一种三环七元环卫矛烷——3-羟基卫矛宁E（5）的结构，已通过对二维核磁共振数据的广泛分析以及将其光谱数据与4的光谱数据进行比较得以确定。
