Fukuyama Yoshiyasu, Minami Hiroyuki, Matsuo Asami, Kitamura Kanako, Akizuki Mie, Kubo Miwa, Kodama Mitsuaki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Chem Pharm Bull (Tokyo). 2002 Mar;50(3):368-71. doi: 10.1248/cpb.50.368.
New five seven-membered vibsane-type diterpenes named 5-epi-vibsanin C, 5-epi-vibsanin H, 5-epi-vibsanin K, 18-O-methyl-5-epi-vibsanin K and 5-epi-vibsanin E have been isolated from the leaves of Viburnum awabuki (Caplifoliaceae). Their structures have been elucidated by analyses of spectroscopic data and comparison of their spectral data with those of the previously known seven-membered vibsane-type diterpenes. The occurrence of these seven-membered vibsane-type diterpenes with a cis relationship on the C-5 and C-10 positions in nature have been predicted by conformational analysis of vibsanin B, an eleven-membered vibsane-type diterpene. Vibsanin C, 5-epi-vibsanin C and 5-epi-vibsanin H exhibited moderate cytotoxic activities on KB cells.
从珊瑚树（忍冬科）的叶子中分离出了五种新的七元紫杉烷型二萜，分别命名为5-表-紫杉烷C、5-表-紫杉烷H、5-表-紫杉烷K、18-O-甲基-5-表-紫杉烷K和5-表-紫杉烷E。通过光谱数据分析以及将它们的光谱数据与先前已知的七元紫杉烷型二萜的光谱数据进行比较，阐明了它们的结构。通过对十一元紫杉烷型二萜紫杉烷B的构象分析，预测了自然界中这些在C-5和C-10位具有顺式关系的七元紫杉烷型二萜的存在。紫杉烷C、5-表-紫杉烷C和5-表-紫杉烷H对KB细胞表现出中等的细胞毒性活性。
