Kaestner L, Bollensdorff C, Bernhardt I
Biophysics Section, Institute of Biology, Humboldt University Berlin, Invalidenstrasse 42, 10115, Berlin, Germany.
Biochim Biophys Acta. 1999 Feb 4;1417(1):9-15. doi: 10.1016/s0005-2736(98)00240-5.
Using the patch-clamp technique, a non-selective voltage-activated Na+ and K+ channel in the human red blood cell membrane was found. The channel operates only at positive membrane potentials from about +30 mV (inside positive) onwards. For sodium and potassium ions, similar conductances of about 21 pS were determined. Together with the recently described K+(Na+)/H+ exchanger, this channel is responsible for the increase of residual K+ and Na+ fluxes across the human red blood cell membrane when the cells are suspended in low ionic strength medium.
利用膜片钳技术，在人红细胞膜中发现了一种非选择性电压激活的钠通道和钾通道。该通道仅在膜电位从约+30mV（内正外负）开始的正向膜电位下运作。对于钠离子和钾离子，测定出类似的电导，约为21皮西门子。与最近描述的钾（钠）/氢交换体一起，当细胞悬浮于低离子强度介质中时，该通道负责跨人红细胞膜的残余钾离子和钠离子通量的增加。
