Busse T, Belitz H D
Z Lebensm Unters Forsch. 1976 Dec 31;162(4):357-64. doi: 10.1007/BF01122788.
The cathepsins D from trout muscle and from bovine spleen, as well as cathepsin A from bovine spleen are inhibited by a crude proteinase inhibitor from potato tubers. Cathepsins C and B1 are not inhibited. It was shown by isoelectric focussing that several inhibitors for cathepsin D are present in potatoes. Those with isoelectric points at pH 9.2, 9.1, 9.0, 8.9, 8.5 inhibit cathepsins D both from trout muscle and from bovine spleen. In addition some inhibitors with isoelectric points at pH 6.6, 6.5, and 6.2 were observed, which inhibit cathepsin D from trout muscle only.
来自鳟鱼肌肉和牛脾脏的组织蛋白酶D以及来自牛脾脏的组织蛋白酶A，受到来自马铃薯块茎的一种粗蛋白酶抑制剂的抑制。组织蛋白酶C和B1不受抑制。通过等电聚焦表明，马铃薯中存在几种组织蛋白酶D抑制剂。等电点在pH 9.2、9.1、9.0、8.9、8.5的抑制剂，对来自鳟鱼肌肉和牛脾脏的组织蛋白酶D均有抑制作用。此外，还观察到一些等电点在pH 6.6、6.5和6.2的抑制剂，它们仅抑制来自鳟鱼肌肉的组织蛋白酶D。
