Loge J H, Abrahamsen A F, Ekeberg O, Kaasa S
Department of Behavioural Sciences in Medicine, University of Oslo, Norway.
Ann Oncol. 1999 Jan;10(1):71-7. doi: 10.1023/a:1008315525997.
Late complications after curative treatment of Hodgkin's disease are of special relevance because most of the cured are young adults. The aims of the present study were: (1) to compare health-related quality of life (HRQOL) in Hodgkin's disease (HD) survivors with normative data from the general Norwegian population and (2) to examine the relations between disease/treatment characteristics and HRQOL in the HD survivors.
459 HD survivors aged 19-74 years (mean 44.0, SD 11.8) treated at the Norwegian Radium Hospital 1971-1991 were approached in 1994 and compared to norms from 2214 subjects approached in 1996. The norms are representative of the general Norwegian population. HRQOL was assessed by the Short Form 36 (SF-36), which measures HRQOL in eight separate scales (0 = worst health state, 100 = best health state).
The HD survivors had lower scores than the normal controls on all scales after adjustment for age, gender and educational levels. Statistically significant differences (P < 0.01) were found in general health (10.4), physical functioning (6.1), role limitations (physical, 9.3), physical functioning (3.6) and in vitality (4.7). Patients with disease stage IB-IIB had the lowest scores on all scales. The differences in relation to stage/substage reached statistical significance (P < 0.01) in physical functioning and in role limitations (physical). Time since diagnosis, types of primary treatment or having relapsed were not associated with statistically significant differences in HRQOL.
Long-term HD survivors have poorer HRQOL, primarily in physical health, than the general Norwegian population.
霍奇金淋巴瘤根治性治疗后的晚期并发症具有特殊意义，因为大多数治愈者为年轻成年人。本研究的目的是：（1）将霍奇金淋巴瘤（HD）幸存者的健康相关生活质量（HRQOL）与挪威普通人群的标准数据进行比较；（2）研究HD幸存者的疾病/治疗特征与HRQOL之间的关系。
1994年对1971年至1991年在挪威镭医院接受治疗的459名19至74岁（平均44.0岁，标准差11.8）的HD幸存者进行了调查，并与1996年调查的2214名受试者的标准数据进行比较。这些标准数据代表了挪威普通人群。HRQOL通过简短健康调查问卷（SF-36）进行评估，该问卷在八个独立量表中测量HRQOL（0 = 最差健康状态，100 = 最佳健康状态）。
在对年龄、性别和教育水平进行调整后，HD幸存者在所有量表上的得分均低于正常对照组。在总体健康（10.4）、身体功能（6.1）、角色限制（身体方面，9.3）、身体功能（3.6）和活力（4.7）方面发现了具有统计学意义的差异（P < 0.01）。疾病分期为IB-IIB期的患者在所有量表上得分最低。在身体功能和角色限制（身体方面）方面，与分期/亚分期相关的差异具有统计学意义（P < 0.01）。自诊断以来的时间、初始治疗类型或是否复发与HRQOL的统计学显著差异无关。
长期HD幸存者的HRQOL较挪威普通人群更差，主要体现在身体健康方面。
