Loge J H, Abrahamsen A F, Ekeberg O, Kaasa S
Department of Behavioral Sciences in Medicine, University of Oslo, Norway.
J Clin Oncol. 1999 Jan;17(1):253-61. doi: 10.1200/JCO.1999.17.1.253.
To estimate the level of fatigue and frequency of fatigue cases among Hodgkin's disease survivors (HDS) and compare them with normative data from the general population.
A cross-sectional follow-up study was done of 557 HDS (age range, 19 to 74 years) treated at the Norwegian Radium Hospital from 1971 to 1991. The sample was approached by mail, and their data were compared with normative data from 2,214 controls (age range, 19 to 74 years) representative of the general Norwegian population. Of the 557 HDS, 459 (82%) responded. The mean age (+/- SD) at the time of study was 44+/-12 years, and the mean observation time was 12+/-6 years. The Fatigue Questionnaire (11 items) measures physical and mental fatigue. Two systems of scoring were used, dichotomized (0, 0, 1, and 1) and Likert (0, 1, 2, and 3). Total fatigue (TF) constitutes the sum of all the Likert scores. Caseness was defined as a total dichotomized score of > or =4 and fatigue that lasted 6 months or longer.
The HDS had significantly higher levels of TF than the controls (14.3 v 12.2) (P < .001). Fatigue among the HDS equaled that of the controls in poorest health. More HDS (61%) than controls (31%) reported fatigue symptoms lasting 6 months or longer (P < .001). Fatigue cases were more frequent among HDS (men, 24%; women, 27%) than among the controls (men, 9%; women, 12%) (P < .001). Disease stage/substage IB/IIB predicted fatigue caseness (P = .03). No significant associations were found between treatment characteristics and fatigue.
Hodgkin's disease survivors are considerably more fatigued than the general population and report fatigue of a substantially longer duration.
评估霍奇金病幸存者（HDS）的疲劳程度及疲劳病例的发生率，并将其与普通人群的标准数据进行比较。
对1971年至1991年在挪威镭医院接受治疗的557例HDS（年龄范围19至74岁）进行了一项横断面随访研究。通过邮件联系样本，并将他们的数据与来自2214名代表挪威普通人群的对照者（年龄范围19至74岁）的标准数据进行比较。557例HDS中，459例（82%）作出了回应。研究时的平均年龄（±标准差）为44±12岁，平均观察时间为12±6年。疲劳问卷（11项）测量身体和精神疲劳。使用了两种评分系统，二分法（0、0、1和1）和李克特量表（0、1、2和3）。总疲劳（TF）为所有李克特量表得分之和。病例定义为二分法总分≥4分且疲劳持续6个月或更长时间。
HDS的TF水平显著高于对照组（14.3对12.2）（P<.001）。HDS的疲劳程度与健康状况最差的对照组相当。报告疲劳症状持续6个月或更长时间的HDS（61%）多于对照组（31%）（P<.001）。HDS中疲劳病例（男性24%；女性27%）比对照组（男性9%；女性12%）更常见（P<.001）。疾病分期/亚分期IB/IIB可预测疲劳病例（P=.03）。未发现治疗特征与疲劳之间存在显著关联。
霍奇金病幸存者比普通人群疲劳得多，且报告的疲劳持续时间长得多。
