Norell M C, Andersson H S, Nicholls I A
Bioorganic Chemistry Laboratory, University of Kalmar, Sweden.
J Mol Recognit. 1998 Winter;11(1-6):98-102. doi: 10.1002/(SICI)1099-1352(199812)11:1/6<98::AID-JMR399>3.0.CO;2-Y.
The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non-imprinted (reference) polymers have been observed.
为了确定茶碱分子印迹聚合物作为控释药物剂型的潜力，对其模板释放动力学进行了研究。通过预聚合模板 - 单体络合的证明以及产物聚合物配体选择性的HPLC研究，揭示了这些聚合物配体选择性的基础。释放动力学显示出对模板负载量和pH的依赖性。已观察到印迹聚合物和非印迹（参考）聚合物在释放特性上存在微小差异。
