Puoci F, Iemma F, Muzzalupo R, Spizzirri U G, Trombino S, Cassano R, Picci N
Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy.
Macromol Biosci. 2004 Jan 21;4(1):22-6. doi: 10.1002/mabi.200300035.
Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and non-imprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule. Photomicrography of spherical molecularly imprinted polymers (SMIPs).
通过一种新型沉淀聚合法，以柳氮磺胺吡啶（用于结肠疾病的前药）为模板制备了球形分子印迹聚合物（SMIPs）。将柳氮磺胺吡啶掺入SMIPs和球形非印迹聚合物（对照物）中，然后评估生物活性剂在不同pH值下的释放速率。已观察到印迹聚合物和非印迹聚合物在释放特性上存在显著差异。这为开发能够调节特定分子释放的药物释放系统开辟了可能性。球形分子印迹聚合物（SMIPs）的显微照片。
