Li B S, Su Q N, Kiyama H, Miki N, Robinow D R, Zhang L
Department of Pharmacology I, Osaka University Medicine School, Suita, Japan.
Neurosci Lett. 1999 Feb 5;260(3):149-52. doi: 10.1016/s0304-3940(98)00979-3.
Gicerin is an integral membrane glycoprotein which mediates cell-cell and cell-extracellular matrix (ECM) interactions in the nervous system. We studied gicerin expression in the hypoglossal nucleus post transection using in situ hybridization and immunocytochemistry. We found that hypoglossal nerve injury resulted in a significant increase in gicerin expression. Its expression levels reached peak values in reactive astrocytes surrounding axotomized motoneurons of the ipsilateral hypoglossal nucleus 14 days after hypoglossal nerve injury. The results indicate that gicerin is up-regulated during nerve regeneration, suggesting that gicerin expressed in the reactive astrocytes might be involved in the processes of nerve regeneration.
吉塞林是一种整合膜糖蛋白，介导神经系统中的细胞间和细胞与细胞外基质（ECM）的相互作用。我们使用原位杂交和免疫细胞化学技术研究了横断后舌下神经核中吉塞林的表达。我们发现舌下神经损伤导致吉塞林表达显著增加。在舌下神经损伤后14天，其表达水平在同侧舌下神经核轴突切断的运动神经元周围的反应性星形胶质细胞中达到峰值。结果表明，吉塞林在神经再生过程中上调，提示反应性星形胶质细胞中表达的吉塞林可能参与神经再生过程。
