Hiroi Satoshi, Tsukamoto Yasuhiro, Sasaki Fumihiko, Miki Naomasa, Taira Eiichi
Department of Veterinary Anatomy, Osaka Prefecture University, Graduate School of Agriculture and Biological Sciences, 1-1 Gakuencho, Sakai, Osaka 599-8531, Japan.
FEBS Lett. 2003 Nov 20;554(3):311-4. doi: 10.1016/s0014-5793(03)01176-1.
We have examined the role of gicerin, an immunoglobulin superfamily cell adhesion molecule, in chick sciatic nerves during development and regeneration. Gicerin was expressed in the spinal cord, dorsal root ganglion (DRG) and sciatic nerves in embryos, but declined after hatching. Neurite extensions from explant cultures of the DRG were promoted on gicerin's ligands, which were inhibited by an anti-gicerin antibody. Furthermore, gicerin expression was upregulated in the regenerating sciatic nerves, DRG and dorsal horn of the spinal cord after injury to the sciatic nerve. These results indicate that gicerin might participate in the development and regeneration of sciatic nerves.
我们研究了免疫球蛋白超家族细胞粘附分子gicerin在鸡坐骨神经发育和再生过程中的作用。Gicerin在胚胎期的脊髓、背根神经节（DRG）和坐骨神经中表达，但在孵化后下降。DRG外植体培养物的神经突延伸在gicerin的配体上得到促进，而这种促进作用被抗gicerin抗体抑制。此外，坐骨神经损伤后，再生的坐骨神经、DRG和脊髓背角中的gicerin表达上调。这些结果表明，gicerin可能参与坐骨神经的发育和再生。
