Sorrentino D, Ferraccioli G F, De Vita S, Labombarda A, Boiocchi M, Bartoli E
Gastrointestinal Unit, University of Udine, Italy.
Ital J Gastroenterol Hepatol. 1998 Oct;30 Suppl 3:S310-2.
Evidence is accumulating that Helicobacter pylori infection may be closely associated with autoimmunity. However, whether autoimmunity plays a causal role in the pathogenesis of some of the diseases attributed to this bacterium or whether it is rather an epiphenomenon remains to be determined. In this brief review, a summary is made of current knowledge regarding the potential general mechanisms by which Helicobacter pylori causes mucosal damage. A review is then made of the evidence linking this bacterium to the production of different gastric autoantibodies. Finally, the reported association between Helicobacter pylori infection and some known autoimmune diseases is discussed. Although the data are still not sufficiently complete to draw definite conclusions, autoimmunity appears to be an important aspect of this infection and will certainly become a major field of study in the next few years.
越来越多的证据表明，幽门螺杆菌感染可能与自身免疫密切相关。然而，自身免疫在某些归因于这种细菌的疾病发病机制中是否起因果作用，或者它是否仅仅是一种附带现象，仍有待确定。在这篇简短的综述中，总结了关于幽门螺杆菌导致黏膜损伤的潜在一般机制的现有知识。接着回顾了将这种细菌与不同胃自身抗体产生联系起来的证据。最后，讨论了报道的幽门螺杆菌感染与一些已知自身免疫性疾病之间的关联。尽管数据仍不够完整，无法得出明确结论，但自身免疫似乎是这种感染的一个重要方面，并且肯定会在未来几年成为一个主要的研究领域。
