Grote M, Reichart P A, Hopf U
Abteilung für Oralchirurgie und zahnärztliche Röntgenologie, Zentrum für Zahnmedizin, Universitätsklinikum Charité.
Mund Kiefer Gesichtschir. 1999 Jan;3(1):30-3. doi: 10.1007/s100060050089.
The present study evaluated the risk of hepatitis C virus-infected (HCV) patients in Germany to develop oral lichen planus (OLP). We screened 127 patients with chronic HCV-infection for OLP. In three of 127 patients (2.4%) OLP was found. Twenty-four patients with OLP were examined for hepatitis C. Only one patient (4.2%) was positive for HCV-RNA. Our data show no increased prevalence for OLP in German patients infected with HCV. Also no increased rate of HCV infection in OLP patients was found in this study. Further studies of HCV-infected patients from different geographical areas and ethnic groups are necessary to determine the rate of OLP in HCV-infection and to clarify whether HCV acts locally to develop OLP, or whether host immune response to HCV is of importance.
本研究评估了德国丙型肝炎病毒感染(HCV)患者发生口腔扁平苔藓(OLP)的风险。我们对127例慢性HCV感染患者进行了OLP筛查。在127例患者中有3例(2.4%)被发现患有OLP。对24例OLP患者进行了丙型肝炎检查。只有1例患者(4.2%)HCV-RNA呈阳性。我们的数据显示,德国HCV感染患者中OLP的患病率没有增加。在本研究中也未发现OLP患者中HCV感染率增加。有必要对来自不同地理区域和种族的HCV感染患者进行进一步研究,以确定HCV感染中OLP的发生率,并阐明HCV是在局部起作用导致OLP,还是宿主对HCV的免疫反应起重要作用。