慢性肝病患者的口腔扁平苔藓

Oral lichen planus in patients with chronic liver diseases.

作者信息

Friedrich R E, Heiland M, El-Moawen A, Dogan A, von Schrenck T, Löning T

机构信息

Dept. of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.

出版信息

Infection. 2003 Dec;31(6):383-6. doi: 10.1007/s15010-003-4074-5.

DOI:10.1007/s15010-003-4074-5

PMID:14735379

Abstract

BACKGROUND

The possible increased risk of oral lichen planus (OLP) in patients with chronic liver diseases is a controversial issue.

PATIENTS AND METHODS

We investigated a total of 156 outpatients with known liver diseases for occurrence of OLP. Hepatitis C virus (HCV) infection was proven for 117 patients (75%) and hepatitis B virus (HBV) infection for 16 patients (10.3%). Four patients were coinfected with HCV and HBV. An alcohol-derived hepatic cirrhosis was found in 23 patients (14.7%). Three patients had a biliary cirrhosis and one had a primary sclerosing cholangitis. Patients suspected of having OLP were transferred to the Department of Oral and Maxillofacial Surgery where excisional biopsies were taken.

RESULTS

Eight patients had a white alteration of the oral mucosa. OLP was suspected in five of them and was confirmed histologically in four. The alteration of the fifth patient disappeared during continued interferon therapy.

CONCLUSION

Our results show that there is no increased prevalence of OLP manifestation in patients suffering from HCV infection.

摘要

背景

慢性肝病患者患口腔扁平苔藓（OLP）的风险可能增加，这是一个有争议的问题。

患者与方法

我们调查了总共156名已知患有肝病的门诊患者是否发生OLP。117名患者（75%）被证实感染丙型肝炎病毒（HCV），16名患者（10.3%）感染乙型肝炎病毒（HBV）。4名患者同时感染HCV和HBV。23名患者（14.7%）患有酒精性肝硬化。3名患者患有胆汁性肝硬化，1名患者患有原发性硬化性胆管炎。疑似患有OLP的患者被转诊至口腔颌面外科，在那里进行切除活检。