Ponomareva N V, Selesneva N D, Jarikov G A
Brain Research Institute, Research Centre for Mental Health, Moscow, Russia.
Neuropsychobiology. 2003;48(3):152-9. doi: 10.1159/000073633.
Twenty first-order relatives of patients with early-onset Alzheimer's disease (AD; mean age 43.7 +/- 1.3 years), 20 patients with early-onset AD (mean age 65.7 +/- 0.9 years) and age-matched normal controls for the relatives and the patients underwent quantitative EEG (qEEG) examinations. In AD patients, delta and theta relative power values were increased and alpha relative power was decreased compared with normal controls. The AD patients' relatives had normal resting EEG parameters. Under hyperventilation in the AD relatives, synchronous high-voltage delta and theta activity and sharp waves were revealed, theta and delta relative powers were increased and alpha relative power was decreased compared with the resting EEG in the same persons. Moreover, under hyperventilation, the theta and delta relative powers in the EEG of the relatives were higher, and the alpha relative power was lower compared with the EEG of normal controls under the same conditions. It is suggested that the excitotoxic processes and oxidative stress underlie the EEG alterations in the AD patients' relatives and that these alterations may be related to the further AD development.
20名早发性阿尔茨海默病（AD；平均年龄43.7±1.3岁）患者的一级亲属、20名早发性AD患者（平均年龄65.7±0.9岁）以及与亲属和患者年龄匹配的正常对照接受了定量脑电图（qEEG）检查。与正常对照相比，AD患者的δ波和θ波相对功率值增加，α波相对功率降低。AD患者的亲属静息脑电图参数正常。在AD亲属进行过度换气时，出现同步高压δ波和θ波活动以及尖波，与同一人静息脑电图相比，θ波和δ波相对功率增加，α波相对功率降低。此外，在过度换气时，与相同条件下正常对照的脑电图相比，亲属脑电图中的θ波和δ波相对功率更高，α波相对功率更低。提示兴奋性毒性过程和氧化应激是AD患者亲属脑电图改变的基础，且这些改变可能与AD的进一步发展有关。
