向大鼠室旁核注射普鲁卡因可降低额叶皮质刺激诱导的交感神经和产热激活。

Procaine injection into the paraventricular nucleus reduces sympathetic and thermogenic activation induced by frontal cortex stimulation in the rat.

作者信息

Monda M, Sullo A, De Luca V, Viggiano A

机构信息

Department of Human Physiology and Integrated Biological Functions, Filippo Bottazzi, Second University of Naples, Italy.

出版信息

Brain Res Bull. 1998 Dec;47(6):657-62. doi: 10.1016/s0361-9230(98)00138-5.

DOI:10.1016/s0361-9230(98)00138-5

PMID:10078622

Abstract

These experiments were designed to test the effect of procaine injection into the paraventricular nucleus on the sympathetic and thermogenic changes induced by frontal cortex stimulation. Oxygen consumption, firing rate of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures (T(IBAT) and T(C)) were monitored in fasted male Sprague-Dawley rats before and 25 min after an electrical stimulation of the frontal cortex. The same variables were monitored in rats with administration of procaine into the paraventricular nucleus. The results show that cortical stimulation raises oxygen consumption, sympathetic neuron firing rates, T(IBAT), and T(C). This increase is reduced by procaine injection. These findings suggest that the paraventricular nucleus plays a key role in the sympathetic and thermogenic changes induced by cortical stimulation.

摘要

这些实验旨在测试向室旁核注射普鲁卡因对额叶皮质刺激所诱导的交感神经和产热变化的影响。在禁食的雄性斯普拉格-道利大鼠中，于额叶皮质电刺激前及刺激后25分钟监测其耗氧量、支配肩胛间棕色脂肪组织（IBAT）的交感神经放电频率，以及IBAT和结肠温度（T(IBAT)和T(C)）。在向室旁核注射普鲁卡因的大鼠中监测相同的变量。结果显示，皮质刺激会提高耗氧量、交感神经元放电频率、T(IBAT)和T(C)。注射普鲁卡因可减轻这种增加。这些发现表明，室旁核在皮质刺激所诱导的交感神经和产热变化中起关键作用。