Kodama H, Kono S, Todoroki I, Honjo S, Sakurai Y, Wakabayashi K, Nishiwaki M, Hamada H, Nishikawa H, Koga H, Ogawa S, Nakagawa K
Department of Public Health, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Int J Obes Relat Metab Disord. 1999 Feb;23(2):211-6. doi: 10.1038/sj.ijo.0800781.
To examine the relation of body mass index (BMI) and waist-to-hip ratio (WHR) to gallstones and postcholecystectomy risk in middle-aged Japanese men.
Cross-sectional study.
We used 174 men with prevalent gallstones, 104 with postcholecystectomy and 6909 with normal gallbladder in the consecutive series of 7637 men aged 48-59y receiving a preretirement health examination at four hospitals of the Japan Self-Defense Forces between 1986 and 1994.
Gallbladder status was assessed by abdominal ultrasonography after an overnight fast. BMI was calculated as weight in kilogram divided by height in square meters, and WHR was used as a measure of central obesity. Analysis of the WHR was limited to a subset of data for the period 1991-1994 (gallstones 113, postcholecystectomy 66 and normal gallbladder 4410).
After adjustment for hospital, rank in the Self-Defense Forces, cigarette smoking, alcohol use and glucose tolerance, BMI was significantly associated with an increased risk of both prevalent gallstones and postcholecystectomy. WHR also showed a significant positive association with each of the two conditions. When BMI and WHR were mutually adjusted for, both of the obesity indices tended to be associated positively with prevalent gallstones and postcholecystectomy.
These findings indicate that obesity is associated with increased gallstone risk in men.
研究中年日本男性的体重指数（BMI）和腰臀比（WHR）与胆结石及胆囊切除术后风险的关系。
横断面研究。
我们选取了1986年至1994年间在日本自卫队四家医院接受退休前健康检查的7637名48 - 59岁男性中的连续系列样本，其中174名患有胆结石，104名接受过胆囊切除术，6909名胆囊正常。
禁食过夜后通过腹部超声评估胆囊状况。BMI计算为体重（千克）除以身高（平方米），WHR用作中心性肥胖的指标。对WHR的分析仅限于1991 - 1994年期间的部分数据（胆结石患者113名，胆囊切除术后患者66名，胆囊正常者4410名）。
在对医院、自卫队军衔、吸烟、饮酒和糖耐量进行调整后，BMI与胆结石患病率及胆囊切除术后风险的增加显著相关。WHR与这两种情况也均呈显著正相关。当对BMI和WHR进行相互调整后，两种肥胖指标均倾向于与胆结石患病率及胆囊切除术后风险呈正相关。
这些发现表明肥胖与男性胆结石风险增加有关。
