Kono S, Shinchi K, Ikeda N, Yanai F, Imanishi K
Department of Public Health, National Defense Medical College, Saitama, Japan.
Am J Epidemiol. 1992 Oct 1;136(7):787-94. doi: 10.1093/aje/136.7.787.
Risk factors of gallstone disease were investigated in male self-defense officials who received, between October 1986 and December 1990, a retirement health examination at the Self-Defense Forces Fukuoka Hospital, Fukuoka, Japan. Gallbladder ultrasonography, successfully performed with 2,739 of 2,756 men, found 61 men with gallstones and 38 men with previous removal of the gallbladder; the overall prevalence of gallstone disease was 3.6%. Multiple logistic regression analysis assessed the risk of gallstone disease in relation to smoking, alcohol use, body mass index, glucose tolerance, and rank. Alcohol use was associated with a decreased risk, and body mass index was positively related to gallstone disease. Men with impaired glucose tolerance had a slightly elevated risk, whereas diabetes mellitus was not associated with gallstone disease. Analysis for prevalent gallstones and the postcholecystectomy state showed an inverse association of alcohol use with the latter; a positive association with impaired glucose tolerance was also confined primarily to the latter condition. These findings provide little support for a protective effect of alcohol use in the formation of gallstones. It was inconclusive whether impaired glucose tolerance was associated selectively with postcholecystectomy.
1986年10月至1990年12月期间，在日本福冈自卫队医院接受退休健康检查的男性自卫官中，对胆结石疾病的危险因素进行了调查。在2756名男性中，成功对2739人进行了胆囊超声检查，发现61人患有胆结石，38人曾接受过胆囊切除术；胆结石疾病的总体患病率为3.6%。多因素logistic回归分析评估了胆结石疾病与吸烟、饮酒、体重指数、糖耐量和军衔的风险关系。饮酒与风险降低有关，体重指数与胆结石疾病呈正相关。糖耐量受损的男性风险略有升高，而糖尿病与胆结石疾病无关。对现患胆结石和胆囊切除术后状态的分析显示，饮酒与后者呈负相关；与糖耐量受损的正相关也主要局限于后者。这些发现几乎没有支持饮酒对胆结石形成有保护作用的观点。糖耐量受损是否与胆囊切除术后有选择性关联尚无定论。
