Kono S, Shinchi K, Todoroki I, Honjo S, Sakurai Y, Wakabayashi K, Imanishi K, Nishikawa H, Ogawa S, Katsurada M
Dept. of Public Health, National Defense Medical College, Tokorozawa, Japan.
Scand J Gastroenterol. 1995 Apr;30(4):372-6. doi: 10.3109/00365529509093293.
Risk factors for gallstones are not fully understood, especially in men. Obesity and other risk factors for gallstone disease were investigated in Japanese men based on gallbladder ultrasonography.
Forty-one men with gallstones, 31 with postcholecystectomy state, and 2044 with a normal gallbladder were identified among 2228 men aged 49-55 years who received a retirement health examination at three hospitals of the Japan Self-Defense Forces between 1991 and 1992. Glucose tolerance was determined with a 75-g oral glucose tolerance test.
Body mass index was not associated with gallstones, although it was significantly, positively related to postcholecystectomy. Waist to hip circumference ratio tended to be weakly associated with gallstones. Diabetes mellitus was associated only with postcholecystectomy. Smoking, alcohol intake, and physical activity were not measurably related to either gallstones or postcholecystectomy.
The present study failed to substantiate an association of gallstone risk with either obesity or any other risk factor. Further observation is needed in view of the limited study power.
胆结石的危险因素尚未完全明确，尤其是在男性中。基于胆囊超声检查，对日本男性的肥胖及其他胆结石疾病危险因素进行了调查。
在1991年至1992年间于日本自卫队三家医院接受退休健康检查的2228名49 - 55岁男性中，确定了41名胆结石患者、31名胆囊切除术后患者以及2044名胆囊正常者。通过75克口服葡萄糖耐量试验测定葡萄糖耐量。
体重指数与胆结石无关，尽管它与胆囊切除术后状态呈显著正相关。腰臀围比与胆结石的关联较弱。糖尿病仅与胆囊切除术后状态有关。吸烟、饮酒和身体活动与胆结石或胆囊切除术后状态均无明显关联。
本研究未能证实胆结石风险与肥胖或任何其他危险因素之间存在关联。鉴于研究能力有限，需要进一步观察。
