Verity M A, Wolfson W L
Acta Neuropathol. 1976 Oct 15;36(2):117-24. doi: 10.1007/BF00685274.
Neuropathologic findings in 2 cases of cerebral lymphomatoid granulomatosis with sequelae are presented. A 30-year old male with macular rash and pulmonary lymphomatoid granulomatosis responded to Prednisone terapy but developed acute intracranial hypertension with coma. A necrotizing hemorrhagic lesion was evident in the left putamen surrounded by diffuse and perivascular atypical lymphoplasmacytic infiltration. An 18-year old girl developed pulmonary lymphomatoid granulomatosis, diplopia, slurred speech and right hemiparesis. Brain scan, angiography and EEG suggested a left fronto-parietal mass assumed to represent lymphomatoid granulomatosis. She responded well to cerebral irradiation, intrathecal methotrexate and cytoxan but relapsed with seizures and increasing respiratory insufficiency. At autopsy, stigmata of cerebral lymphomatoid granulomatosis were absent but a parenchymatous degeneration consistent with disseminated necrotizing leukoencephalopathy following antileukemic therapy in children, was found.
本文报告了2例伴有后遗症的脑淋巴瘤样肉芽肿病的神经病理学发现。一名30岁男性，有黄斑皮疹和肺部淋巴瘤样肉芽肿病，对泼尼松治疗有反应，但出现急性颅内高压并昏迷。左侧壳核可见坏死性出血性病变，周围有弥漫性和血管周围非典型淋巴浆细胞浸润。一名18岁女孩患肺部淋巴瘤样肉芽肿病，出现复视、言语不清和右侧偏瘫。脑部扫描、血管造影和脑电图提示左侧额顶叶肿块，推测为淋巴瘤样肉芽肿病。她对脑部放疗、鞘内注射甲氨蝶呤和环磷酰胺反应良好，但复发时出现癫痫发作且呼吸功能不全加重。尸检时，未发现脑淋巴瘤样肉芽肿病的特征，但发现了与儿童抗白血病治疗后播散性坏死性白质脑病一致的实质性变性。
