Bone R C, Vernon M, Sobonya R E, Rendon H
Am J Med. 1978 Oct;65(4):709-16. doi: 10.1016/0002-9343(78)90860-4.
A 24 year old man had a nonproductive cough and chest pain. Chest roentgenogram showed a diffuse infiltrate, and pulmonary function studies showed restrictive lung disease. Extremity weakness, deteriorating mental status and neuropathy progressed as pulmonary findings diminished on corticosteroid therapy. Lung biopsy showed lymphomatoid granulomatosis. The neurologic status deteriorated despite treatment with Cytoxan, intrathecal methotrexate and brain irradiation. Autopsy showed mass lesions of lymphomatoid granulomatosis in the brain and healed lesions in the lungs. A review of the neurologic and pulmonary findings in reported cases show that diminution of pulmonary disease with progression of neurologic disease manifest by mass lesion is unusual. Since the etiology, prognosis and prevalence of this disease remains undefined, all patients with this disease should be reported on.
一名24岁男性出现干咳和胸痛。胸部X线片显示弥漫性浸润，肺功能检查显示限制性肺病。在使用皮质类固醇治疗后肺部症状减轻的同时，肢体无力、精神状态恶化和神经病变却在进展。肺活检显示为淋巴瘤样肉芽肿病。尽管使用了环磷酰胺、鞘内注射甲氨蝶呤和脑部放疗进行治疗，神经状态仍恶化。尸检显示脑部有淋巴瘤样肉芽肿病的肿块病变，肺部有愈合的病变。对已报道病例的神经和肺部表现进行回顾发现，随着以肿块病变为表现的神经疾病进展，肺部疾病减轻的情况并不常见。由于该疾病的病因、预后和患病率仍不明确，所有患有该疾病的患者都应予以报道。
