Bowen S E, Daniel J, Balster R L
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0310, USA.
Drug Alcohol Depend. 1999 Feb 1;53(3):239-45. doi: 10.1016/s0376-8716(98)00139-2.
Inhalant abuse has existed for a considerable period of time and it is currently one of the most prevalent drug abuse problems in the world. One repercussion from using these compounds is that abuse may result in lethality. In an attempt to better understand the deaths associated with inhalant abuse, the authors surveyed the death records from the Commonwealth of Virginia from 1987 to 1996. Examination of the state records identified 39 deaths related to inhalant abuse during this time period. While no significant increase or decrease in the death rate was observed across the time period investigated, all regions of Virginia were affected, with the rates being highest in the northern and eastern regions of the state. Age of death ranged from 13 to 42 years with the majority of deaths (70%) occurring at 22 years of age or younger. Ninety-five per cent of the individuals were male, with volatile substance abuse deaths accounting for 0.3% of all deaths in males aged 13-22 years. The chief volatile substances used were gas fuels (46%), predominately butane and propane, chlorofluorocarbons (26%), chlorinated hydrocarbons and alkylbenzenes (21%), and other volatile substances including volatile anesthetics. Deaths associated with the abuse of butane and toluene were more likely to be traumatic, but all substances appeared capable of killing directly by their toxic effects, probably through cardiac and/or respiratory mechanisms. The ramifications of these findings for regulation and prevention are addressed.
吸入剂滥用已经存在了相当长的一段时间,目前它是世界上最普遍的药物滥用问题之一。使用这些化合物的一个后果是滥用可能导致死亡。为了更好地了解与吸入剂滥用相关的死亡情况,作者调查了弗吉尼亚州1987年至1996年的死亡记录。对该州记录的审查确定在这一时期有39例与吸入剂滥用相关的死亡。在所调查的时间段内,未观察到死亡率有显著上升或下降,但弗吉尼亚州的所有地区都受到了影响,该州北部和东部地区的死亡率最高。死亡年龄在13岁至42岁之间,大多数死亡(70%)发生在22岁及以下。95%的个体为男性,挥发性物质滥用死亡占13至22岁男性所有死亡人数的0.3%。使用的主要挥发性物质为气体燃料(46%),主要是丁烷和丙烷,氯氟烃(26%),氯代烃和烷基苯(21%),以及其他挥发性物质,包括挥发性麻醉剂。与丁烷和甲苯滥用相关的死亡更有可能是外伤性的,但所有物质似乎都能够通过其毒性作用直接致死,可能是通过心脏和/或呼吸机制。文中讨论了这些发现对监管和预防工作的影响。