Naydeck B L, Sutton-Tyrrell K, Schiller K D, Newman A B, Kuller L H
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
Am J Cardiol. 1999 Mar 1;83(5):759-64. doi: 10.1016/s0002-9149(98)00985-0.
An association between abdominal aortic aneurysm (AAA) and atherosclerotic disease has been recognized and may be due to shared risk factors. A consistent relation between blood pressure and AAA has not been found. AAA was compared between those with and without isolated systolic hypertension (ISH) and prevalence of aortic atherosclerosis was evaluated. Abdominal aortic ultrasound was performed in 266 people, 143 with ISH and 123 age-similar controls. AAA was defined as an infrarenal aortic diameter of > or = 3.0 cm or an infrarenal-to-suprarenal diameter ratio of > or = 1.2. The average age of participants was 73 years. Overall prevalence of AAA was 9.4%, 11.9% in those with ISH and 6.5% among normotensives (p = 0.134). Multivariate analysis revealed male gender (p <0.001), higher low-density lipoprotein (p <0.001), higher pulse pressure (p = 0.032), and current smoking (p = 0.012) to be independent predictors of AAA. When evaluating aortic atherosclerosis, those with AAA had significantly larger diameters of the iliac arteries along with greater intimamedia thickness of the iliac arteries. Those with and without aneurysms had a similar prevalence of plaque (89% to 96%), but measured plaques tended to be larger among those with than without AAA (p <0.001). Progression of AAA after 1 year was observed in 8 participants, with a mean diameter change of 3.42 mm. AAA was found to be independently associated with pulse pressure but not with systolic blood pressure. Patients with AAA also had greater wall thickness and greater diameter of the iliac arteries, which are probably associated with the underlying disease process.
腹主动脉瘤（AAA）与动脉粥样硬化疾病之间的关联已得到认可，这可能归因于共同的风险因素。尚未发现血压与AAA之间存在一致的关系。对患有和未患有单纯收缩期高血压（ISH）的人群进行了AAA比较，并评估了主动脉粥样硬化的患病率。对266人进行了腹主动脉超声检查，其中143人患有ISH，123人为年龄相仿的对照组。AAA定义为肾下腹主动脉直径≥3.0 cm或肾下与肾上直径比≥1.2。参与者的平均年龄为73岁。AAA的总体患病率为9.4%，ISH患者中为11.9%，血压正常者中为6.5%（p = 0.134）。多变量分析显示，男性（p <0.001）、较高的低密度脂蛋白（p <0.001）、较高的脉压（p = 0.032）和当前吸烟（p = 0.012）是AAA的独立预测因素。在评估主动脉粥样硬化时，患有AAA的患者髂动脉直径明显更大，同时髂动脉内膜中层厚度更大。有动脉瘤和无动脉瘤的患者斑块患病率相似（89%至96%），但有AAA的患者测量的斑块往往比无AAA的患者更大（p <0.001）。8名参与者在1年后观察到AAA进展，平均直径变化为3.42 mm。发现AAA与脉压独立相关，但与收缩压无关。患有AAA的患者髂动脉壁厚度和直径也更大，这可能与潜在的疾病过程有关。
