Carpenter W T, Buchanan R W, Kirkpatrick B, Lann H D, Breier A F, Summerfelt A T
Maryland Psychiatric Research Center and the Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
Am J Psychiatry. 1999 Mar;156(3):412-8. doi: 10.1176/ajp.156.3.412.
Dose reduction strategies for the maintenance treatment of schizophrenia are designed to maintain the benefits of antipsychotic drug therapy while reducing risks. Previous strategies with decanoate preparations have been based on the use of lower doses per injection to achieve dose reduction; these strategies have achieved dose reduction but have resulted in some increase in symptoms. The authors tested a new dose reduction approach: increasing the interval between injections during intramuscular decanoate antipsychotic treatment.
Fifty outpatients with schizophrenia or schizoaffective disorder were randomly assigned to receive 25 mg of fluphenazine decanoate intramuscularly either every 2 weeks or every 6 weeks for 54 weeks in a double-blind design.
The two dose regimens did not differ significantly in relapse, symptom, or side effect measures. The every-6-weeks regimen was associated with a significant reduction in total antipsychotic exposure.
The use of injections every 6 weeks instead of every 2 weeks may increase compliance and improve patients' comfort as well as decrease cumulative antipsychotic exposure, without increasing relapse rates or symptoms.
精神分裂症维持治疗的剂量减少策略旨在在降低风险的同时维持抗精神病药物治疗的益处。以往癸酸酯制剂的策略是基于每次注射使用较低剂量以实现剂量减少；这些策略实现了剂量减少，但导致症状有所增加。作者测试了一种新的剂量减少方法：在肌肉注射癸酸酯抗精神病药物治疗期间增加注射间隔。
50例精神分裂症或分裂情感性障碍门诊患者被随机分配，采用双盲设计，每2周或每6周肌肉注射25mg氟奋乃静癸酸酯，共54周。
两种剂量方案在复发、症状或副作用测量方面无显著差异。每6周一次的方案与抗精神病药物总暴露量显著减少相关。
每6周注射一次而非每2周注射一次，可能会提高依从性，改善患者舒适度，并减少抗精神病药物的累积暴露量，同时不增加复发率或症状。
Zotero 插件