Looney R J, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham G N
Department of Medicine, University of Rochester, Rochester, New York 14642, USA.
Clin Immunol. 1999 Feb;90(2):213-9. doi: 10.1006/clim.1998.4638.
The effect of prior cytomegalovirus (CMV) infection on the immune system was evaluated in young and elderly volunteers. Prevalence of IgG antibodies to CMV was higher in the elderly volunteers. In both age groups, there was a strong association with CMV seropositivity and increased number of CD28- CD4 or CD8 T cells, as well as with increased numbers of T cells expressing CD56 or DR. Although these changes have previously been reported to be age-related, they were independent of age when CMV serological status was taken into account. In contrast, both age group and CMV status were important determinants of the total number of T cells, the number of CD8 T cells, and the number of CD8 T cells expressing CD45RA or CD28. These findings indicate that prior infection with CMV, as reflected by CMV serological status, has important effects on T cell subsets and surface markers and must be considered whenever evaluating age-related changes in immunological parameters.
在年轻和老年志愿者中评估了既往巨细胞病毒（CMV）感染对免疫系统的影响。老年志愿者中CMV IgG抗体的流行率更高。在两个年龄组中，CMV血清阳性与CD28-CD4或CD8 T细胞数量增加以及表达CD56或DR的T细胞数量增加密切相关。尽管这些变化先前已被报道与年龄有关，但在考虑CMV血清学状态时，它们与年龄无关。相反，年龄组和CMV状态都是T细胞总数、CD8 T细胞数量以及表达CD45RA或CD28的CD8 T细胞数量的重要决定因素。这些发现表明，CMV血清学状态所反映的既往CMV感染对T细胞亚群和表面标志物有重要影响，在评估免疫参数的年龄相关变化时必须予以考虑。
