Beardsley P M, Lemaire G A, Meisch R A
Psychopharmacology (Berl). 1978 Sep 15;59(1):7-11. doi: 10.1007/BF00428023.
Dippers filled with water or an ethanol solution were presented to male Wistar rats contingent on lever-pressing under a concurrent fixed-ratio 1 (water) fixed-ratio 1 (ethanol) schedule. During Phase I, when maintenance feedings were given during instead of following the daily 3-h sessions, the feedings increased drinking of both 8% (w/v) ethanol and water, with 8% ethanol being consumed in greater volumes than water. In Phase II, a 28-day transitional period from the food-deprived to the food-satiated state, continuous access to food during 3-h sessions moderately decreased 8% ethanol intake, and increased water intake and total liquid intake (water plus 8% ethanol). In Phase III, concurrent water and ethanol intake of food-satiated rats was compared over two identical series of ethanol concentrations (8, 11.3, 16, 22.6, 32, and 8% retest). Food was freely available in both the operant conditioning chambers and home cages. The number of dipper presentations of ethanol exceeded presentations of water for each rat at each concentration studied. Presentations of water were low in number and did not vary with the ethanol concentration. As the ethanol concentration was increased, the number of ethanol presentations decreased, while the quantity consumed (mg/100 g body weight/h) generally increased.
将装满水或乙醇溶液的饮水器呈现给雄性Wistar大鼠，呈现条件是在固定比率1（水）固定比率1（乙醇）的并发程序下按压杠杆。在第一阶段，当维持性喂食在每日3小时实验时段内而非实验时段之后进行时，喂食增加了8%（重量/体积）乙醇和水的饮用量，8%乙醇的饮用量大于水。在第二阶段，即从食物剥夺状态到食物饱足状态的28天过渡期，在3小时实验时段内持续提供食物适度降低了8%乙醇的摄入量，并增加了水摄入量和总液体摄入量（水加8%乙醇）。在第三阶段，比较了食物饱足大鼠在两个相同系列乙醇浓度（8、11.3、16、22.6、32以及8%复测）下的同时饮水和乙醇摄入量。在操作性条件反射箱和饲养笼中均可自由获取食物。在所研究的每个浓度下，每只大鼠乙醇饮水器呈现的次数均超过水的呈现次数。水的呈现次数较少，且不随乙醇浓度变化。随着乙醇浓度增加，乙醇呈现次数减少，而消耗量（毫克/100克体重/小时）总体上增加。
