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乙醇作为大鼠的强化物:同时获取水以及水和乙醇位置交替的影响。

Ethanol as a reinforcer for rats: effects of concurrent access to water and alternate positions of water and ethanol.

作者信息

Meisch R A, Beardsley P

出版信息

Psychopharmacologia. 1975 Jul 23;43(1):19-23. doi: 10.1007/BF00437609.

DOI:10.1007/BF00437609
PMID:1161991
Abstract

Water and ethanol solutions were concurrently made available on a continuous reinforcement schedule to 4 food-deprived male albino rats during daily 1-hr sessions in an operant conditioning chamber equipped with 2 levers and 2 liquid dippers. The number of ethanol reinforcements substantially exceeded the number of water reinforcements for each rat at each concentration studied (8, 16, and 32% w/v). Water reinforcements were low in number and did not vary with ethanol concentration. As the ethanol concentration was increased, the number of ethanol reinforcements obtained decreased, while the quantity consumed (mg/100 g of body weight/hr) increased. The highest rate of responding occurred at the beginning of the session.

摘要

在配备有2根杠杆和2个液体滴管的操作性条件反射箱中,每天1小时的实验时段内,以连续强化程序同时向4只食物剥夺的雄性白化大鼠提供水和乙醇溶液。在所研究的每种浓度(8%、16%和32%重量/体积)下,每只大鼠的乙醇强化次数显著超过水强化次数。水强化次数较少,且不随乙醇浓度变化。随着乙醇浓度的增加,获得的乙醇强化次数减少,而消耗量(毫克/100克体重/小时)增加。最高反应率出现在实验时段开始时。

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Ethanol as a reinforcer for rats: effects of concurrent access to water and alternate positions of water and ethanol.乙醇作为大鼠的强化物:同时获取水以及水和乙醇位置交替的影响。
Psychopharmacologia. 1975 Jul 23;43(1):19-23. doi: 10.1007/BF00437609.
2
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本文引用的文献

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Changes in learning, extinction, and fluid preferences as a function of chronic alcohol consumption in rats.
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Preference factors in experimental alcoholism.实验性酒精中毒中的偏好因素。
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Rapid establishment of ethanol as a reinforcer for rats.乙醇作为大鼠强化物的快速确立。
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按压杠杆反应作为大鼠乙醇偏好的一种测量方法。
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Mouse strain differences in operant self-administration of ethanol.小鼠品系在乙醇操作性自我给药方面的差异。
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Voluntary ethanol consumption in the absence of hunger and thirst drives.在没有饥饿和口渴驱力的情况下自愿摄入乙醇。
Psychopharmacology (Berl). 1986;88(1):101-4. doi: 10.1007/BF00310521.
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Nicotine maintains robust self-administration in rats on a limited-access schedule.尼古丁能使大鼠在限量供应的情况下保持强烈的自我给药行为。
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Suppression of ethanol-reinforced lever pressing by delaying food availability.通过延迟食物供应来抑制乙醇强化的杠杆按压行为。
J Exp Anal Behav. 1977 Nov;28(3):271-83. doi: 10.1901/jeab.1977.28-271.
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Ethanol drinking by rhesus monkeys as a function of concentration.恒河猴饮酒量与乙醇浓度的关系。
Psychopharmacology (Berl). 1978 Apr 28;57(2):133-6. doi: 10.1007/BF00426877.
9
Ethanol-reinforced behavior of rats with concurrent access to food and water.同时获取食物和水的大鼠的乙醇强化行为。
Psychopharmacology (Berl). 1978 Sep 15;59(1):7-11. doi: 10.1007/BF00428023.
10
Concurrent etonitazene and water intake in rats: role of taste, olfaction, and auditory stimuli.大鼠中依托尼秦与水摄入的同时发生:味觉、嗅觉和听觉刺激的作用。
Psychopharmacology (Berl). 1979 Jun 28;64(1):1-7. doi: 10.1007/BF00427336.
4
Ethanol as a reinforcer: effects of fixed-ratio size and food deprivation.乙醇作为一种强化物:固定比率大小和食物剥夺的影响。
Psychopharmacologia. 1973 Jan 1;28(2):171-83. doi: 10.1007/BF00421402.
5
Ethanol intake as a function of concentration during food deprivation and satiation.在食物剥夺和饱腹感期间,乙醇摄入量与浓度的函数关系。
Pharmacol Biochem Behav. 1974 Sep-Oct;2(5):589-96. doi: 10.1016/0091-3057(74)90025-2.