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恒河猴饮酒量与乙醇浓度的关系。

Ethanol drinking by rhesus monkeys as a function of concentration.

作者信息

Henningfield J E, Meisch R A

出版信息

Psychopharmacology (Berl). 1978 Apr 28;57(2):133-6. doi: 10.1007/BF00426877.

DOI:10.1007/BF00426877
PMID:418445
Abstract

Ethanol deliveries maintained fixed-ratio (FR) responding of three rhesus monkeys during daily 3-h sessions. At FR values of 8 or 16, ethanol concentration was varied in the sequence 0 (water), 8, 11.3, 16, 22.6 32, 8, and 0% (w/v). As the ethanol concentration increased, number of liquid deliveries decreased somewhat. Blood ethanol levels were usually greater than 200 mg% and occasionally greater than 300 mg%.

摘要

在每天3小时的实验过程中，给三只恒河猴提供乙醇，维持其固定比例（FR）反应。当固定比例值为8或16时，乙醇浓度按0（水）、8、11.3、16、22.6、32、8和0%（w/v）的顺序变化。随着乙醇浓度的增加，液体输送量略有减少。血液乙醇水平通常大于200mg%，偶尔大于300mg%。

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Adv Exp Med Biol. 1977;85B:443-63. doi: 10.1007/978-1-4615-9038-5_29.
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本文引用的文献

1
Ethanol intake in the absence of concurrent food reinforcement.在没有同时存在食物强化的情况下摄入乙醇。
Psychopharmacologia. 1971;22(1):72-9. doi: 10.1007/BF00401469.
2
Rapid establishment of ethanol as a reinforcer for rats.乙醇作为大鼠强化物的快速确立。
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3
Ethanol intake as a function of concentration during food deprivation and satiation.在食物剥夺和饱腹感期间，乙醇摄入量与浓度的函数关系。
调节含 α5 亚基的 GABA A 受体可改变恒河猴的饮酒行为。
Alcohol Clin Exp Res. 2013 Apr;37(4):624-34. doi: 10.1111/acer.12018. Epub 2012 Nov 5.
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Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure.使用调味剂消退程序控制恒河猴口服乙醇摄入量并使其与行为相关
Alcohol Clin Exp Res. 2004 Jun;28(6):873-83. doi: 10.1097/01.alc.0000128895.99379.8c.
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Relative reinforcing effects of different oral ethanol doses in rhesus monkeys.不同口服乙醇剂量对恒河猴的相对强化作用。
J Exp Anal Behav. 2002 Jan;77(1):49-64. doi: 10.1901/jeab.2002.77-49.
6
Concurrent pentobarbital- and saccharin-maintained responding: effects of saccharin concentration and schedule conditions.戊巴比妥和糖精维持的同时反应：糖精浓度和程序条件的影响
Psychopharmacology (Berl). 1993;112(2-3):204-10. doi: 10.1007/BF02244912.
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Pentobarbital self-administration in rhesus monkeys: drug concentration and fixed-ratio size interactions.恒河猴戊巴比妥自我给药：药物浓度与固定比率大小的相互作用。
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Fixed-ratio schedules of oral ethanol self-administration in inbred mouse strains.近交系小鼠口服乙醇自我给药的固定比例时间表。
Psychopharmacology (Berl). 1988;96(4):431-6. doi: 10.1007/BF02180019.
9
Alcoholic-like drinking in simian social groups.猿猴社会群体中的类酒精性饮酒行为。
Psychopharmacology (Berl). 1987;92(2):196-205. doi: 10.1007/BF00177915.
10
Ethanol-reinforced behavior of rats with concurrent access to food and water.同时获取食物和水的大鼠的乙醇强化行为。
Psychopharmacology (Berl). 1978 Sep 15;59(1):7-11. doi: 10.1007/BF00428023.
Pharmacol Biochem Behav. 1974 Sep-Oct;2(5):589-96. doi: 10.1016/0091-3057(74)90025-2.
4
The reinforcing property of ethanol in the rhesus monkey. I. Initiation, maintenance and termination of intravenous ethanol-reinforced responding.乙醇对恒河猴的强化特性。I. 静脉注射乙醇强化反应的启动、维持和终止。
Ann N Y Acad Sci. 1973 Apr 30;215:162-5. doi: 10.1111/j.1749-6632.1973.tb28263.x.
5
The function of schedule-induced polydipsia in establishing ethanol as a positive reinforcer.程序性诱导多饮在将乙醇确立为阳性强化物中的作用。
Pharmacol Rev. 1975 Dec;27(4):465-73.
6
Ethanol as a reinforcer for rats: effects of concurrent access to water and alternate positions of water and ethanol.乙醇作为大鼠的强化物：同时获取水以及水和乙醇位置交替的影响。
Psychopharmacologia. 1975 Jul 23;43(1):19-23. doi: 10.1007/BF00437609.
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Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey.
Pharmacol Biochem Behav. 1976 Nov;5(5):577-52. doi: 10.1016/0091-3057(76)90272-0.
8
Drinking device for rhesus monkeys.恒河猴饮水装置
Pharmacol Biochem Behav. 1976 May;4(5):609-10. doi: 10.1016/0091-3057(76)90204-5.
9
Establishment of ethanol as a reinforcer for rhesus monkeys via the oral route: initial results.通过口服途径将乙醇确立为恒河猴的强化物：初步结果。
Adv Exp Med Biol. 1975;59:323-42. doi: 10.1007/978-1-4757-0632-1_23.
10
Drinking of ethanol by rhesus monkeys: experimental strategies for establishing ethanol as a reinforcer.恒河猴饮用乙醇：将乙醇确立为强化物的实验策略。
Adv Exp Med Biol. 1977;85B:443-63. doi: 10.1007/978-1-4615-9038-5_29.