氯氮卓和5-羟色胺受体拮抗剂对小鼠吗啡诱导的运动兴奋的相反作用。
Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice.
作者信息
Sansone M
出版信息
Psychopharmacology (Berl). 1982;78(1):54-7. doi: 10.1007/BF00470588.
PMID:6815697
Abstract
Chlordiazepoxide and two serotonin receptor antagonists showed opposite effects when tested for their influence on morphine-induced locomotor stimulation in mice. Chlordiazepoxide enhanced morphine-induced hyperactivity, which was antagonized by cyproheptadine and mianserin. The results indicate that the enhancement of morphine-induced locomotor stimulation is not attributable to an antiserotonergic action of the benzodiazepine compound.
摘要
在对小鼠进行氯氮卓和两种血清素受体拮抗剂对吗啡诱导的运动刺激影响的测试时，它们呈现出相反的效果。氯氮卓增强了吗啡诱导的多动，而这种增强作用被赛庚啶和米安色林所拮抗。结果表明，吗啡诱导的运动刺激增强并非归因于苯二氮卓类化合物的抗血清素作用。
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