脑源性神经营养因子（BDNF）和神经营养素-4（NT-4），而非神经营养素-3（NT-3），在无神经元活动的情况下促进抑制性突触的发育。

BDNF and NT-4, but not NT-3, promote development of inhibitory synapses in the absence of neuronal activity.

作者信息

Seil F J

机构信息

Neurology Research (151 N), VA Medical Center and Departments of Neurology and Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR 97201, USA.

出版信息

Brain Res. 1999 Feb 13;818(2):561-4. doi: 10.1016/s0006-8993(98)01304-3.

DOI:10.1016/s0006-8993(98)01304-3

PMID:10082848

Abstract

Development of the full complement of inhibitory synapses in cerebellar cultures requires the presence of neuronal activity. The neurotrophins, BDNF, NT-3 and NT-4, were applied to cerebellar explants during activity blockade. Control numbers of inhibitory Purkinje cell axosomatic synapses developed in the presence of the TrkB receptor ligands, BDNF and NT-4, but not the TrkC receptor ligand, NT-3. The results suggest that BDNF and NT-4 have a role in the promotion of activity-dependent inhibitory synaptogenesis.

摘要

小脑培养物中抑制性突触完全形成需要神经元活动的存在。在活动阻断期间，将神经营养因子BDNF、NT-3和NT-4应用于小脑外植体。在TrkB受体配体BDNF和NT-4存在的情况下，抑制性浦肯野细胞轴体突触的数量正常发育，但TrkC受体配体NT-3不存在时则不然。结果表明，BDNF和NT-4在促进活动依赖性抑制性突触形成中起作用。