Bulik C M, Sullivan P F, Fear J L, Pickering A, Dawn A, McCullin M
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, 23298, USA.
J Clin Psychiatry. 1999 Feb;60(2):130-5; quiz 135-7. doi: 10.4088/jcp.v60n0212.
Women who have anorexia nervosa may experience difficulties with fertility and reproduction.
We examined fertility and reproductive history in 66 women who had a history of anorexia nervosa (DSM-III-R) and 98 randomly selected community controls as part of a follow-up investigation examining the course of anorexia nervosa.
Although women with a history of anorexia nervosa and controls did not differ on rate of pregnancy, mean number of pregnancies per woman, or age at first pregnancy, women with anorexia nervosa had significantly more miscarriages and cesarean deliveries, and the offspring of women with anorexia nervosa were significantly more likely to be born prematurely and were of lower birth weight than offspring of controls. There were no differences between women with active versus remitted anorexia nervosa on any of these measures; however, offspring of anorexic women with no history of bulimia nervosa had significantly lower body weight than offspring of anorexic women with a lifetime history of bulimia nervosa.
Our results argue for intensive prenatal care for women with both active and remitted anorexia nervosa to ensure adequate prenatal nutrition and fetal development.
患有神经性厌食症的女性在生育和生殖方面可能会遇到困难。
作为一项研究神经性厌食症病程的随访调查的一部分，我们调查了66名有神经性厌食症病史（DSM-III-R）的女性以及98名随机选取的社区对照者的生育情况和生殖史。
尽管有神经性厌食症病史的女性与对照组在怀孕率、每名女性的平均怀孕次数或首次怀孕年龄方面没有差异，但有神经性厌食症的女性流产和剖宫产的次数明显更多，而且有神经性厌食症的女性的后代早产的可能性明显更高，出生体重也低于对照组的后代。在这些指标上，处于活跃期与缓解期的神经性厌食症女性之间没有差异；然而，没有神经性贪食症病史的厌食症女性的后代体重明显低于有终身神经性贪食症病史的厌食症女性的后代。
我们的研究结果表明，对于处于活跃期和缓解期的神经性厌食症女性，都应提供强化的产前护理，以确保充足的产前营养和胎儿发育。
