Lambert B, Jacquemin C
Ann Endocrinol (Paris). 1976 Mar-Apr;37(2):103-4.
Lipolysis in rat fat pads was studied by determination of free fatty acid and glycerol production in various experimental conditions (absence or presence of glucose, adrenaline and insulin). These results were compared to the accumulation of endogenous prostaglandins E2 and F2 alpha during lipolysis. In the absence of glucose the prostaglandin production followed the adrenaline-ininduced fluctuations in released free fatty acids both in the presence or absence of insulin. In the presence of glucose and insulin, a drop in prostaglandin accumulation was observed whereas free fatty acid production was strongly stimulated. These results suggest either that free fatty acid composition is modified influencing the acitvity of prostaglandin synthetase, or that there exists a specific mechanism controlling prostaglandin synthesis.
通过测定在各种实验条件下（有无葡萄糖、肾上腺素和胰岛素）大鼠脂肪垫中游离脂肪酸和甘油的生成量，研究了脂肪分解情况。将这些结果与脂肪分解过程中内源性前列腺素E2和F2α的积累情况进行了比较。在无葡萄糖的情况下，无论有无胰岛素，前列腺素的生成都随肾上腺素诱导的游离脂肪酸释放波动而变化。在有葡萄糖和胰岛素存在时，观察到前列腺素积累下降，而游离脂肪酸生成受到强烈刺激。这些结果表明，要么游离脂肪酸组成发生改变影响了前列腺素合成酶的活性，要么存在一种控制前列腺素合成的特定机制。
