Lipinski B A, Mathias M M
Prostaglandins. 1978 Dec;16(6):957-63. doi: 10.1016/0090-6980(78)90112-0.
The influence of dietary fat on prostaglandin production and lipolysis was tested in basal and norepinephrine stimulated adipocytes isolated from the epididymal fat pads of fasted rats. Seven diets varying in fat calories and polyunsaturation were utilized. No basal differences were noted for prostaglandin E2 production or lipolysis. Norepinephrine stimulated prostaglandin E2 and F2alpha production was significantly (P less than 0.01) increased with greater polyunsaturation of fat, but not by increased fat calories. Norepinephrine stimulated lipolysis was depressed by an increase in fat calories but was unaffected by the degree of polyunsaturation of fat. This is in vitro evidence against the concept that prostaglandins play a feedback regulator role in fat cell lipolysis since no correlation could be made between the two parameters.
在基础状态下以及在去甲肾上腺素刺激的情况下，对从禁食大鼠附睾脂肪垫分离出的脂肪细胞进行检测，以研究膳食脂肪对前列腺素生成及脂肪分解的影响。使用了七种脂肪热量和多不饱和程度各异的饮食。在前列腺素E2生成或脂肪分解方面，未观察到基础状态下的差异。脂肪的多不饱和程度越高，去甲肾上腺素刺激的前列腺素E2和F2α生成显著（P小于0.01）增加，但脂肪热量增加则无此作用。脂肪热量增加会抑制去甲肾上腺素刺激的脂肪分解，但脂肪的多不饱和程度对此无影响。这是体外实验证据，反对前列腺素在脂肪细胞脂肪分解中起反馈调节作用这一概念，因为这两个参数之间没有相关性。
