Fraschini F, Cesarani A, Alpini D, Esposti D, Stankov B M
Department of Pharmacology, University of Milan, Italy.
Biol Signals Recept. 1999 Jan-Apr;8(1-2):111-9. doi: 10.1159/000014578.
In order to evaluate a possible correlation between melatonin, the cerebellum and, consequently, human balance, a double-blind pilot study was performed in 5 subjects with random administration of different doses of melatonin. Before and 1 h after a single administration, a complete otoneurological examination was performed. This first pilot study revealed that melatonin had effects on human equilibrium although these effects were not dosage related and were different in individual subjects. On the basis of these results, a second study was performed. Fourteen healthy volunteers were investigated before and 1 h after administration of a single dose of 10 mg melatonin. The otoneurological examination was restricted to the evaluation of: horizontal saccades, horizontal sinusoidal smooth pursuit, eyes open, eyes closed and head retroflexed static posturography. All subjects showed a decrease in posturographic performances, especially in the simplest test (eyes open) and half of them (6 out of 13) showed also impairment of eye movements. These results confirm the role of melatonin in the control of sensorimotor performances, and the cerebellar receptors might be correlated with the control of human balance.
为了评估褪黑素、小脑以及由此而来的人体平衡之间可能存在的相关性，对5名受试者进行了一项双盲试验研究，随机给予不同剂量的褪黑素。在单次给药前和给药后1小时，进行了全面的耳神经学检查。这项初步试验研究表明，褪黑素对人体平衡有影响，尽管这些影响与剂量无关，且在个体受试者中有所不同。基于这些结果，进行了第二项研究。对14名健康志愿者在单次服用10毫克褪黑素前和给药后1小时进行了调查。耳神经学检查仅限于评估：水平扫视、水平正弦曲线平稳跟踪、睁眼、闭眼以及头部后伸静态姿势描记法。所有受试者的姿势描记表现均有所下降，尤其是在最简单的测试（睁眼）中，其中一半受试者（13名中的6名）还出现了眼球运动障碍。这些结果证实了褪黑素在控制感觉运动表现中的作用，并且小脑受体可能与人体平衡的控制相关。
