Amstrup Anne Kristine, Sikjaer Tanja, Mosekilde Leif, Rejnmark Lars
Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Tage-Hansens Gade 2 DK-Aarhus C, 8000, Aarhus, Denmark.
Nutr J. 2015 Sep 30;14:102. doi: 10.1186/s12937-015-0093-1.
Melatonin is often used as a sleeping aid in elderly adults. As previous studies suggest a protective role of melatonin against osteoporosis, it is important to document its safety. Treatment should not cause any hangover effect that could potentially lead to falls and fractures. We therefore aimed to evaluate the effect of melatonin on balance- and muscle function.
In a double-blind placebo-controlled study, we randomized 81 postmenopausal women with osteopenia to receive 1 or 3 mg melatonin, or placebo nightly for 12 months. Postural balance as well as muscle function was measured. In addition, we assessed quality of life and sleep at baseline and after 12 months treatment.
Compared to placebo, one-year treatment with melatonin did not affect postural balance or risk of falls. Furthermore, no significant changes between groups were observed in muscle strength in neither upper- nor lower extremities. Treatment did not affect quality of life or sleep. However, in the subgroup of women with sleep disturbances at baseline, a trend towards an improved sleep quality was seen (p = 0.08).
Treatment with melatonin is safe in postmenopausal women with osteopenia. There is no hangover effect affecting balance- and muscle function following the intake of melatonin. In women with a good quality of sleep, melatonin has no effect, however in poor quality of sleep, small doses of melatonin trended towards improving the quality.
(# NCT01690000).
褪黑素常用于老年人助眠。鉴于先前研究表明褪黑素对骨质疏松具有保护作用，记录其安全性很重要。治疗不应引起任何可能导致跌倒和骨折的宿醉效应。因此，我们旨在评估褪黑素对平衡和肌肉功能的影响。
在一项双盲安慰剂对照研究中，我们将81名患有骨质减少的绝经后女性随机分为三组，分别每晚服用1毫克或3毫克褪黑素，或服用安慰剂，为期12个月。测量姿势平衡和肌肉功能。此外，我们在基线和治疗12个月后评估生活质量和睡眠情况。
与安慰剂相比，褪黑素治疗一年对姿势平衡或跌倒风险没有影响。此外，上肢和下肢肌肉力量在各组之间均未观察到显著变化。治疗对生活质量或睡眠没有影响。然而，在基线时有睡眠障碍的女性亚组中，观察到睡眠质量有改善的趋势（p = 0.08）。
褪黑素治疗对患有骨质减少的绝经后女性是安全的。摄入褪黑素后不会产生影响平衡和肌肉功能的宿醉效应。在睡眠质量良好的女性中，褪黑素没有效果，然而在睡眠质量差的女性中，小剂量褪黑素倾向于改善睡眠质量。
（# NCT01690000）
