Ogilvie D, McCollum J P, Packer S, Manning J, Oyesiku J, Muller D P, Harries J T
Arch Dis Child. 1976 Oct;51(10):790-5. doi: 10.1136/adc.51.10.790.
24-hour urinary outputs of oxalate, calcium, and magnesium have been determined in a total of 62 children aged 3 months to 17 years who fell into the following groups: (i) 16 normal controls, (ii) 3 with primary hyperoxaluria, (iii) 9 with small and/or large intestinal resections, (iv) 9 with untreated coeliac disease, (v) 5 with pancreatic dysfunction, and (vi) a miscellaneous group of 20 children with a variety of intestinal disorders. Taken as a whole, 58% of patients with intestinal disorders had hyperoxaluria, and of these 7% had urinary outputs of oxalate which fell within the range seen in primary hyperoxaluria. The proportion of children with hyperoxaluria in the different diagnostic groups was as follows: intestinal resections (78%), coeliac disease (67%), pancreatic dysfunction (80%), and miscellaneous (45%). 35% of the patients with hyperoxaluria had hypercalciuria, whereas magnesium excretion was normal in all subjects studied. In 2 patients treatment of the underlying condition was accompanied by a return of oxalate excretion to normal. These results indicate that hyperoxaluria and hypercalciuria are common in children with a variety of intestinal disorders, and that such children may be at risk of developing renal calculi without early diagnosis and treatment.
对总共62名年龄在3个月至17岁的儿童测定了24小时尿草酸、钙和镁的排出量，这些儿童分为以下几组：（i）16名正常对照；（ii）3名原发性高草酸尿症患者；（iii）9名接受小肠和/或大肠切除术的患者；（iv）9名未经治疗的乳糜泻患者；（v）5名胰腺功能障碍患者；（vi）一组由20名患有各种肠道疾病的儿童组成的杂项组。总体而言，58%的肠道疾病患者有高草酸尿症，其中7%的尿草酸排出量在原发性高草酸尿症所见范围内。不同诊断组中高草酸尿症儿童的比例如下：小肠和/或大肠切除术（78%）、乳糜泻（67%）、胰腺功能障碍（80%）和杂项组（45%）。35%的高草酸尿症患者有高钙尿症，而所有研究对象的镁排泄均正常。2名患者在治疗基础疾病后草酸排泄恢复正常。这些结果表明，高草酸尿症和高钙尿症在患有各种肠道疾病的儿童中很常见，并且这些儿童在没有早期诊断和治疗的情况下可能有患肾结石的风险。
