Barilla D E, Notz C, Kennedy D, Pak C Y
Am J Med. 1978 Apr;64(4):579-85. doi: 10.1016/0002-9343(78)90576-4.
Intestinal absorption of oxalate was assessed indirectly from the increase in renal oxalate excretion following the oral administration of 5 mmol of stable oxalate. When sodium oxalate alone was given without divalent cations to patients in the fasting state, the urinary oxalate increased promptly (within 2 hours). The increase was more prominent and sustained in those with ileal disease (ileal resection or jujunoileal bypass); thus, 35 per cent of the orally administered oxalate eventually appeared in the urine in the group with ileal disease, 8 per cent in the group with stones (renal and absorptive hypercalciurias) and 9 per cent in the control group. This hyperexcretion of oxalate could be largely, but not totally, ameliorated by the concurrent oral administration of divalent cations. Although urinary oxalate decreased significantly following the oral administration of calcium or magnesium, hyperoxaluria persisted in most patients. The results suggested that the hyperabsorption of oxalate in ileal disease cannot be accounted for solely by an increased absorbable oxalate pool associated with calcium-fatty acid complexation. Moreover, although urinary oxalate decreased, urinary calcium increased concurrently when either calcium or magnesium was given. Thus, there was no significant change or increase in the urinary state of saturation with respect to calcium oxalate.
通过口服5 mmol稳定草酸盐后肾草酸盐排泄量的增加，间接评估肠道对草酸盐的吸收情况。当在禁食状态下仅给患者服用草酸钠而不给予二价阳离子时，尿草酸盐迅速增加（2小时内）。在患有回肠疾病（回肠切除或空肠回肠旁路术）的患者中，这种增加更为显著且持续；因此，在患有回肠疾病的组中，口服草酸盐最终有35%出现在尿液中，结石组（肾性和吸收性高钙尿症）为8%，对照组为9%。同时口服二价阳离子可在很大程度上（但并非完全）改善这种草酸盐排泄过多的情况。尽管口服钙或镁后尿草酸盐显著降低，但大多数患者的高草酸尿症仍然存在。结果表明，回肠疾病中草酸盐的过度吸收不能仅通过与钙 - 脂肪酸络合相关的可吸收草酸盐池增加来解释。此外，尽管尿草酸盐降低，但给予钙或镁时尿钙同时增加。因此，草酸钙的尿饱和状态没有显著变化或增加。
