De Vos N, Song C, Lin A h, Demedts P, Wauters A, Neels H, De Jongh R, Kenis G, Bosmans E, Altamura C, Maes M
Clinical Research Center for Mental Health (CRC-MH), Antwerp, Belgium.
Neuropsychobiology. 1999;39(3):144-50. doi: 10.1159/000026574.
Recently, it was reported that there may be an activation of the inflammatory response system in detoxified alcohol-dependent patients without apparent liver disease (AWLD). The aims of the present study were to examine serum zinc (Zn) concentrations, total serum protein (TSP) and patterns obtained in the electrophoretically separated protein fractions in relation to serum interleukin-6 (IL-6) and IL-8 concentrations in detoxified AWLD patients. Zn, TSP, SP electrophoresis, and serum IL-6 and IL-8 concentrations were determined in detoxified AWLD patients and age-matched healthy volunteers. Serum Zn, TSP and the serum concentrations of albumin (Alb) and the beta fraction were significantly lower in detoxified AWLD patients than in healthy volunteers. The percentage of the alpha2 fraction was significantly higher in detoxified AWLD patients. Lower serum Zn in detoxified AWLD patients was attributable to lowered serum Alb. Lower serum Alb was significantly and negatively correlated to increased serum IL-8. The percentage of the alpha1 and alpha2 fractions were significantly and positively related to serum IL-6 and IL-8. The results show that there is an in vivo activation of the inflammatory response system in detoxified AWLD patients and that lower serum Zn may be causally related to lower serum Alb.
最近，有报道称，在无明显肝脏疾病的戒酒酒精依赖患者（AWLD）中，炎症反应系统可能被激活。本研究的目的是检测戒酒AWLD患者血清锌（Zn）浓度、总血清蛋白（TSP）以及电泳分离蛋白组分的模式，并分析其与血清白细胞介素-6（IL-6）和IL-8浓度的关系。对戒酒AWLD患者和年龄匹配的健康志愿者测定了Zn、TSP、血清蛋白（SP）电泳以及血清IL-6和IL-8浓度。戒酒AWLD患者的血清Zn、TSP以及白蛋白（Alb）和β组分的血清浓度显著低于健康志愿者。戒酒AWLD患者α2组分的百分比显著更高。戒酒AWLD患者血清Zn降低归因于血清Alb降低。血清Alb降低与血清IL-8升高显著负相关。α1和α2组分的百分比与血清IL-6和IL-8显著正相关。结果表明，戒酒AWLD患者体内存在炎症反应系统的激活，血清Zn降低可能与血清Alb降低存在因果关系。
