Maes M, Lin A, Bosmans E, Vandoolaeghe E, Bonaccorso S, Kenis G, De Jongh R, Verkerk R, Song C, Scharpé S, Neels H
University Department of Psychiatry, Clinical Research Center for Mental Health, Antwerp, Belgium.
Psychiatry Res. 1998 May 8;78(3):151-61. doi: 10.1016/s0165-1781(98)00010-9.
The aims of the present study were to examine (1) the inflammatory response system (IRS), through measurements of serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), sgp130 (the soluble form of the IL-6 transducer signal protein), CC16 (Clara Cell protein; an endogenous anti-cytokine), IL-1R antagonist (IL-1RA), IL-8 and sCD14; and (2) the availability of plasma total tryptophan to the brain in chronic alcoholic patients without apparent liver disease (AWLD). Detoxified AWLD patients had significantly lower plasma tryptophan and serum CC16 and significantly higher serum IL-1RA and IL-8 concentrations than normal volunteers. There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive). The results suggest that (1) there is, in detoxified AWLD patients, an activation of the monocytic arm of cell-mediated immunity and a lowered anti-inflammatory capacity of the serum; and that (2) lower availability of plasma tryptophan to the brain in detoxified AWLD patients is related to activation of the IRS. Lower CC16 may be one factor predisposing chronic alcoholic patients toward infectious disorders.
（1）炎症反应系统（IRS），通过测量血清白细胞介素-6（IL-6）、可溶性IL-6受体（sIL-6R）、sgp130（IL-6转导信号蛋白的可溶性形式）、CC16（克拉拉细胞蛋白；一种内源性抗细胞因子）、IL-1受体拮抗剂（IL-1RA）、IL-8和可溶性CD14；以及（2）无明显肝脏疾病的慢性酒精中毒患者（AWLD）血浆总色氨酸向脑内的供应情况。与正常志愿者相比，已戒酒的AWLD患者血浆色氨酸和血清CC16显著降低，血清IL-1RA和IL-8浓度显著升高。色氨酸向脑内的供应情况与血清IL-6、IL-8和IL-1RA（均为负相关）以及CC16（正相关）之间存在显著相关性。结果表明：（1）在已戒酒的AWLD患者中，细胞介导免疫的单核细胞分支被激活且血清抗炎能力降低；（2）已戒酒的AWLD患者血浆色氨酸向脑内的供应减少与IRS的激活有关。较低的CC16可能是慢性酒精中毒患者易患感染性疾病的一个因素。
