Aube A C, Cherbut C, Barbier M, Xing J H, Roze C, Galmiche J P
Centre de Recherche en Nutrition Humaine, Nantes, France.
Neurogastroenterol Motil. 1999 Feb;11(1):55-62. doi: 10.1046/j.1365-2982.1999.00137.x.
Changes in gastric emptying and orocaecal transit time in patients with ulcerative colitis suggest that disturbances in gut motility may not be restricted to inflamed sites. This study sought to characterize changes in the motility of noninflamed ileum in a rat colitis model and to explore the mechanism(s) potentially involved. The myoelectrical activity of the ileum was recorded in rats with trinitrobenzene sulphonic acid (TNBS)-induced colitis. The degree of ileal and colonic inflammation was assessed by quantification of macroscopic damage and myeloperoxidase activity (MPO). The effect on ileal motility of pretreatment with atropine, indomethacin and NG-nitro-L-arginine-methyl ester (L-NAME) was investigated. TNBS-induced inflammation was restricted to the distal colon, as evidenced by morphological scores and MPO. Colitis was associated with increased frequency of ileal migrating motor complexes, characterized mainly by a decrease in the duration of phases I and III. The occurrence of ileal giant migrating complexes remained unchanged. The myoelectrical changes observed in the ileum persisted after treatment with atropine, indomethacin and L-NAME. Distal colitis is associated with abnormal myoelectrical activity in the noninflamed ileum of rats. Neither acetylcholine nor prostaglandins and nitric oxide seem to be involved.
溃疡性结肠炎患者胃排空和口盲肠转运时间的变化表明，肠道动力障碍可能并不局限于炎症部位。本研究旨在描述大鼠结肠炎模型中非炎症性回肠的动力变化，并探讨可能涉及的机制。记录三硝基苯磺酸（TNBS）诱导的结肠炎大鼠回肠的肌电活动。通过量化宏观损伤和髓过氧化物酶活性（MPO）评估回肠和结肠的炎症程度。研究了阿托品、吲哚美辛和NG-硝基-L-精氨酸甲酯（L-NAME）预处理对回肠动力的影响。形态学评分和MPO表明，TNBS诱导的炎症局限于远端结肠。结肠炎与回肠移行运动复合体频率增加有关，主要表现为I期和III期持续时间缩短。回肠巨大移行复合体的发生率保持不变。用阿托品、吲哚美辛和L-NAME治疗后，回肠观察到的肌电变化持续存在。远端结肠炎与大鼠非炎症性回肠的异常肌电活动有关。乙酰胆碱、前列腺素和一氧化氮似乎均未参与其中。
