Arkowitz R A
Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.
Trends Cell Biol. 1999 Jan;9(1):20-7. doi: 10.1016/s0962-8924(98)01412-3.
Polarized growth in response to external signals is essential for both the internal organization of cells and generation of complex multicellular structures during development. Oriented growth or movement requires specific detection of an external cue, reorganization of the cytoskeleton and subsequent growth or movement. Genetic approaches in both the budding yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum have shed light on the molecular and cellular aspects of growth or movement towards an external signal. This review discusses the mechanisms and signalling pathways that enable yeast and Dictyostelium cells to translate external signals into directed growth and movement, respectively.
响应外部信号的极化生长对于细胞的内部组织以及发育过程中复杂多细胞结构的形成都至关重要。定向生长或运动需要对外部信号进行特定检测、细胞骨架的重组以及随后的生长或运动。在芽殖酵母酿酒酵母和社会性变形虫盘基网柄菌中的遗传学方法，已经揭示了朝着外部信号生长或运动的分子和细胞层面的情况。本综述讨论了使酵母细胞和盘基网柄菌细胞分别将外部信号转化为定向生长和运动的机制及信号通路。
