Pitt G S, Gundersen R E, Devreotes P N
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Semin Cell Biol. 1990 Apr;1(2):99-104.
A G-protein linked signal transduction mechanism controls chemotaxis in eukaryotes. During development the social amoeba Dictyostelium directs chemotaxis towards external cAMP with its G-protein linked cAMP receptor. Interactions of the receptor and G-proteins transduce the chemotactic signal to the interior of the cell and eventually to the motor apparatus. Phosphorylation of the cAMP receptor has been correlated with the cell's ability to adapt to the external cAMP signal. This signal transduction pathway may help to explain the ability of eukaryotic cells to orient within a chemical gradient by the use of spatial cues.
一种G蛋白偶联信号转导机制控制真核生物中的趋化作用。在发育过程中，社会性变形虫盘基网柄菌通过其G蛋白偶联的cAMP受体将趋化作用导向外部cAMP。受体与G蛋白的相互作用将趋化信号转导至细胞内部，并最终传递至运动装置。cAMP受体的磷酸化与细胞适应外部cAMP信号的能力相关。这种信号转导途径可能有助于解释真核细胞利用空间线索在化学梯度中定向的能力。
