Kortholt Arjan, van Haastert Peter J M
Department of Molecular Cell Biology, University of Groningen, Kerklaan 30, 9751NN Haren, The Netherlands.
Cell Signal. 2008 Aug;20(8):1415-22. doi: 10.1016/j.cellsig.2008.02.006. Epub 2008 Apr 1.
Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis.
趋化作用，即细胞朝着一种化合物进行定向移动，是许多细胞的一项基本特性，并且与多种疾病的发生发展相关联。真核生物的趋化作用是一个复杂的过程，涉及梯度感应、细胞极性、细胞骨架重塑以及信号传递。近期在模式生物盘基网柄菌中的研究表明，趋化作用并非依赖单一的分子机制，而是取决于几条相互连接的途径。令人惊讶的是，小G蛋白似乎在所有这些途径中都发挥着重要作用。本综述将总结小G蛋白在盘基网柄菌中的作用，尤其着重强调Ras亚家族在趋化作用中的功能。
