Department of Biology, College of Natural Sciences, Chosun University, Gwangju 501-759, Republic of Korea.
J Microbiol. 2012 Aug;50(4):555-61. doi: 10.1007/s12275-012-2246-7. Epub 2012 Aug 25.
Cell movement involves a coordinated regulation of the cytoskeleton, F-actin-mediated protrusions at the front and myosin-mediated contraction of the posterior of a cell. The small GTPase Rap1 functions as a key regulator in the spatial and temporal control of cytoskeleton reorganization for cell migration. This review outlines the establishment of cell polarity by differential localizations of the cytoskeleton and discusses the spatial and temporal regulation of cytoskeleton reorganization via the Rap1 signaling pathway during chemotaxis with a focus on recent advances in the study of chemotaxis using a simple eukaryotic model organism, Dictyostelium discoideum.
细胞运动涉及细胞骨架的协调调节，前部由 F-肌动蛋白介导的突起和细胞后部的肌球蛋白介导的收缩。小分子 GTP 酶 Rap1 作为细胞迁移中细胞骨架重排的时空控制的关键调节剂发挥作用。本综述概述了细胞极性的建立，讨论了细胞骨架的差异定位，并讨论了通过 Rap1 信号通路在趋化作用过程中细胞骨架重排的时空调节，重点介绍了使用简单真核模式生物盘基网柄菌研究趋化作用的最新进展。
