Reddy K S, Parsons L, Colman L
Quest Diagnostics Inc., San Juan Capistrano, CA 92690, USA.
Cancer Genet Cytogenet. 1999 Mar;109(2):144-9. doi: 10.1016/s0165-4608(98)00162-9.
A 36-year-old man with a 10-year history of Crohn disease (CD) presented with gross hematuria and blasts in his peripheral blood. A chromosome analysis revealed one normal cell and 33 abnormal cells. The stem line was 47,XY,+8. The multiple side lines also had a jumping translocation between chromosome 1q31-32 and 4, 8, 10, 17, and 18 terminal regions. A cytogenetic, morphologic, and immunophenotypic analysis of a bone marrow aspirate and biopsy demonstrated acute myeloid leukemia of monocytic lineage, AML-M5b. In this paper are reviewed (a) the unusual and rare phenomenon of jumping translocations in hematological malignancies and (b) leukemia in CD.
一名患有克罗恩病（CD）10年的36岁男性，出现肉眼血尿且外周血中有原始细胞。染色体分析显示1个正常细胞和33个异常细胞。主干系为47，XY，+8。多条旁系也在1号染色体q31 - 32区域与4、8、10、17和18号染色体末端区域之间存在跳跃易位。对骨髓穿刺和活检进行的细胞遗传学、形态学和免疫表型分析显示为单核细胞系急性髓系白血病，AML - M5b。本文回顾了（a）血液系统恶性肿瘤中跳跃易位这一不寻常且罕见的现象，以及（b）克罗恩病中的白血病。
