Najfeld V, Hauschildt B, Scalise A, Gattani A, Patel R, Ambinder E P, Silverman L R
Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, New York, NY, USA.
Leukemia. 1995 Apr;9(4):634-9.
Jumping translocations are an unusual phenomenon and have been rarely reported in leukemia. We report three patients whose leukemic cells had multiple related clones resulting from unbalanced jumping translocations of 1q and 7q to chromosomes 1, 8, 15, 21 and 22. The chromosome findings, together with limited published reports, suggest that jumping translocations are new non-random rearrangements and may represent poor prognostic biological markers. Although their origin is unknown, circumstantial evidence suggests that telomeric ends of receptor chromosomes may play a role in stabilizing jumping translocations in dividing malignant cells.
跳跃易位是一种罕见的现象，在白血病中鲜有报道。我们报告了三例患者，其白血病细胞因1号染色体长臂和7号染色体长臂向1号、8号、15号、21号和22号染色体的不平衡跳跃易位而产生多个相关克隆。染色体检查结果以及有限的已发表报告表明，跳跃易位是新的非随机重排，可能代表预后不良的生物学标志物。尽管其起源尚不清楚，但间接证据表明，受体染色体的端粒末端可能在分裂的恶性细胞中稳定跳跃易位中发挥作用。
