瑞典轮状病毒疾病负担的发病率及估计数。

Incidence and estimates of the disease burden of rotavirus in Sweden.

作者信息

Johansen K, Bennet R, Bondesson K, Eriksson M, Hedlund K O, De Verdier Klingenberg K, Uhnoo I, Svensson L

机构信息

Department of Virology, Swedish Institute of Infectious Disease Control, Karolinska Institute, Stockholm.

出版信息

Acta Paediatr Suppl. 1999 Jan;88(426):20-3. doi: 10.1111/j.1651-2227.1999.tb14321.x.

DOI:10.1111/j.1651-2227.1999.tb14321.x

PMID:10088907

Abstract

Laboratory and hospitalization data from two children's hospitals with large primary catchment areas and national laboratory and hospitalization data for children under 4 y of age with acute diarrhoea were compiled to estimate the number of hospitalizations and the cost burden associated with rotavirus diarrhoea in Sweden. According to our estimates 1500-1700 rotavirus-associated hospitalizations occur annually in Sweden in children under 4 y of age (3.7 hospitalizations/1000 children/y). This number represents 2.3% of admissions for all diagnoses in children of this age group. The cost of these hospitalizations is 13.5-15 million Swedish crowns (US$1.8-2 million). Serotyping by PCR for two years revealed that serotype 1 (G1) was the most common (49% and 58%, respectively) identified. Serotypes 2-4 were identified in the following proportions G2 (23% and 5%), G3 (21% and 0%) and G4 (7% and 16%). The national laboratory report data for 1993-96 show that as much as 7-13% of rotavirus infections occur in elderly people.

摘要

我们收集了两家拥有大面积主要集水区的儿童医院的实验室和住院数据，以及4岁以下急性腹泻儿童的全国实验室和住院数据，以估算瑞典轮状病毒腹泻的住院人数和成本负担。根据我们的估算，瑞典每年有1500 - 1700例4岁以下儿童因轮状病毒住院（3.7例住院/1000名儿童/年）。这个数字占该年龄组所有诊断入院人数的2.3%。这些住院治疗的费用为1350 - 1500万瑞典克朗（180 - 200万美元）。连续两年通过聚合酶链反应（PCR）进行血清分型显示，1型（G1）血清型最为常见（分别为49%和58%）。2 - 4型血清型的比例如下：G2（23%和5%）、G3（21%和0%）以及G4（7%和16%）。1993 - 1996年的全国实验室报告数据显示，多达7 - 13%的轮状病毒感染发生在老年人中。