Epidemiol Infect. 2006 Oct;134(5):908-16. doi: 10.1017/S0950268806006091. Epub 2006 Apr 4.
Rotaviruses are a major cause of hospitalizations for acute gastroenteritis in developed countries. This review shows the burden of rotavirus disease in < 5-year-old children in Europe. An estimated 72,000-77,000 hospitalizations for community-acquired rotavirus disease occur annually in the 23 million under-fives living in the European Union (EU-25), with a median cost of Euro 1417 per case. Annual hospitalization incidence rates range from 0.3 to 11.9/1000 children < 5 years old (median 3/1000). The median proportion of hospital-acquired rotavirus disease among all cases of hospitalization for rotavirus disease is estimated to be 21%. Countries of the EU-25 require information on the burden of rotavirus disease to support introduction of rotavirus vaccines. Data on cases treated at home, medical visits, and emergency wards as well as rotavirus-associated deaths are limited. To fully evaluate the impact and effectiveness of rotavirus vaccination programmes in Europe, additional epidemiological studies will be critical and desirable.
轮状病毒是发达国家急性胃肠炎住院治疗的主要病因。本综述显示了欧洲5岁以下儿童轮状病毒疾病的负担。在欧盟25国生活的2300万5岁以下儿童中，估计每年有72000 - 77000例因社区获得性轮状病毒疾病住院，每例病例的中位数费用为1417欧元。5岁以下儿童的年住院发病率在0.3至11.9/1000之间（中位数为3/1000）。在所有轮状病毒疾病住院病例中，医院获得性轮状病毒疾病的中位数比例估计为21%。欧盟25国需要有关轮状病毒疾病负担的信息，以支持引入轮状病毒疫苗。关于在家治疗的病例、就诊情况、急诊病房以及轮状病毒相关死亡的数据有限。为了全面评估欧洲轮状病毒疫苗接种计划的影响和效果，开展更多的流行病学研究至关重要且很有必要。
